Publication: Expression of TFF3 during multistep colon carcinogenesis
Authors
John, R. ; El-Rouby, N.M. ; Tomasetto, C. ; Rio, M.C. ; Karam, S.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The pathogenesis of colon cancer is not well
understood. This common type of cancer is generally
believed to occur in a multistep process which involves
alterations of various tumor suppressor genes and
oncogenes during the progression through benign lesions
towards carcinoma. TFF3 is a product of the colonic
epithelium and has been implicated in colonic mucosal
protection and also in the aggressiveness of colon cancer
cells. The aim of this study was to analyze the
expression of TFF3 during propagation towards cancer
development in the human colon. Colonic tissues
representing colitis, adenomatous polyposis,
tubulovillous adenoma, and mucoid/adeno-carcinomas
were processed for immunohistochemistry using an
antibody specific for human TFF3. The results were
correlated with those of PCNA-labeling, quantified, and
compared with those of control tissues obtained from the
safe margin of macroscopically normal colonic mucosa
of patients with colon cancer. The data showed marked
down-regulation of TFF3 expression in adenomatous
polyposis, then TFF3 expression returns to about control
level during adenoma and remains high during mucoidand
adeno-carcinomas. Colonic tissues with highly
invasive cancer cells were characterized by statistically
significant down-regulation of TFF3 expression. The
changes observed in expression of TFF3 showed an
inverse correlation with cell proliferation and suggest
that it might play a protective role against colon
carcinogenesis.
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