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Bioactivity of phytosterols and their production in plant in vitro cultures

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dc.contributor.authorAlmagro Romero, Lorena
dc.contributor.authorMiras Moreno, Begoña
dc.contributor.authorPedreño García, María Ángeles
dc.contributor.authorSabater Jara, Ana Belén
dc.contributor.departmentBiología Vegetal
dc.date.accessioned2025-05-16T11:56:12Z
dc.date.available2025-05-16T11:56:12Z
dc.date.issued2016-09-12
dc.description© 2016 American Chemical Society. This document is the Published Manuscript version of a Published Work that appeared in final form in Journal of Agricultural and Food Chemistry. To access the final edited and published work see https://doi.org/10.1021/acs.jafc.6b02345
dc.description.abstractPhytosterols are a kind of plant metabolite belonging to the triterpene family. These compounds are essential biomolecules for human health, and so they must be taken from foods. β-Sitosterol, campesterol, and stigmasterol are the main phytosterols found in plants. Phytosterols have beneficial effects on human health since they are able to reduce plasma cholesterol levels and have antiinflammatory, antidiabetic, and anticancer activities. However, there are many difficulties in obtaining them, since the levels of these compounds produced from plant raw materials are low and their chemical synthesis is not economically profitable for commercial exploitation. A biotechnological alternative for their production is the use of plant cell and hairy root cultures. This review is focused on the biosynthesis of phytosterols and their function in both plants and humans as well as the different biotechnological strategies to increase phytosterol biosynthesis. Special attention is given to describing new methodologies based on the use of recombinant DNA technology to increase the levels of phytosterols.
dc.formatapplication/pdfes
dc.format.extent10
dc.identifier.citationJournal of Agricultural and Food Chemistry, 2016, Vol. 64, Issue 38, pp. 7049–7058
dc.identifier.doihttps://doi.org/10.1021/acs.jafc.6b02345
dc.identifier.issnPrint: 0021-8561
dc.identifier.issnElectronic: 1520-5118
dc.identifier.urihttp://hdl.handle.net/10201/154784
dc.languageenges
dc.publisherAmerican Chemical Society
dc.relationMinisterio de Economiá y Competitividad (BIO2014-51861-R), Fundación Seneca-Agencia de Ciencia y Tecnología de la Región de Murcia (No. 19876/GERM/15)es
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acs.jafc.6b02345
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBiosynthethic pathway
dc.subjectPhytosterols
dc.subjectIn vitro cultures
dc.titleBioactivity of phytosterols and their production in plant in vitro cultureses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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relation.isAuthorOfPublication.latestForDiscovery26b10f99-26d5-4ed0-a830-5b27d6665ae6
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