Publication: Bioactivity of phytosterols and their production in plant in vitro cultures
Authors
Almagro Romero, Lorena ; Miras Moreno, Begoña ; Pedreño García, María Ángeles ; Sabater Jara, Ana Belén
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Publisher
American Chemical Society
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DOI
https://doi.org/10.1021/acs.jafc.6b02345
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info:eu-repo/semantics/article
Description
© 2016 American Chemical Society. This document is the Published Manuscript version of a Published Work that appeared in final form in Journal of Agricultural and Food Chemistry. To access the final edited and published work see https://doi.org/10.1021/acs.jafc.6b02345
Abstract
Phytosterols are a kind of plant metabolite belonging to the triterpene family. These compounds are essential
biomolecules for human health, and so they must be taken from foods. β-Sitosterol, campesterol, and stigmasterol are the main
phytosterols found in plants. Phytosterols have beneficial effects on human health since they are able to reduce plasma
cholesterol levels and have antiinflammatory, antidiabetic, and anticancer activities. However, there are many difficulties in
obtaining them, since the levels of these compounds produced from plant raw materials are low and their chemical synthesis is
not economically profitable for commercial exploitation. A biotechnological alternative for their production is the use of plant cell
and hairy root cultures. This review is focused on the biosynthesis of phytosterols and their function in both plants and humans
as well as the different biotechnological strategies to increase phytosterol biosynthesis. Special attention is given to describing
new methodologies based on the use of recombinant DNA technology to increase the levels of phytosterols.
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Citation
Journal of Agricultural and Food Chemistry, 2016, Vol. 64, Issue 38, pp. 7049–7058
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