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Melatonin and cannabinoids: mitochondrial-targeted molecules that may reduce inflammaging in neurodegenerative diseases

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dc.contributor.authorGarcía, Sebastián
dc.contributor.authorMartín Giménez, Virna Margarita
dc.contributor.authorMocayar Marón, Feres José
dc.contributor.authorReiter, Russel J.
dc.contributor.authorManucha, Walter
dc.date.accessioned2022-11-30T08:59:39Z
dc.date.available2022-11-30T08:59:39Z
dc.date.issued2020
dc.description.abstractGenerally, the development and progression of neurodegenerative diseases are associated with advancing age, so they are usually diagnosed in late adulthood. A primary mechanism underlying the onset of neurodegenerative diseases is neuroinflammation. Based on this background, the concept of "neuroinflammaging" has emerged. In this deregulated neuroinflammatory process, a variety of immune cells participate, especially glial cells, proinflammatory cytokines, receptors, and subcellular organelles including mitochondria, which are mainly responsible for maintaining redox balance at the cellular level. Senescence and autophagic processes also play a crucial role in the neuroinflammatory disease associated with aging. Of particular interest, melatonin, cannabinoids, and the receptors of both molecules which are closely related, exert beneficial effects on the neuro- inflammatory processes that precede the onset of neurodegenerative pathologies such as Parkinson's and Alzheimer's diseases. Some of these neuroprotective effects are fundamentally related to its anti- inflammatory and antioxidative actions at the mitochondrial level due to the strategic functions of this organelle. The aim of this review is to summarize the most recent advances in the study of neuroinflammation and neurodegeneration associated with age and to consider the use of new mitochondrial therapeutic targets related to the endocannabinoid system and the pineal gland.es
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dc.format.extent12es
dc.identifier.citationHistology and Histopathology Vol. 35, nº8 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-212
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/126088
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMelatonines
dc.subjectCannabinoidses
dc.subjectMitochondriaes
dc.subjectInflammaginges
dc.subjectNeuroinflammationes
dc.subjectNeuroprotectiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMelatonin and cannabinoids: mitochondrial-targeted molecules that may reduce inflammaging in neurodegenerative diseaseses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nº8 (2020)