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Emergence of cfr-Mediated Linezolid Resistance in a Methicillin-Resistant Staphylococcus aureus Epidemic Clone Isolated from Patients with CysticFibrosis

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de Dios Caballero J, 2015. 60(3)-1878-82. .pdf(1.73 MB)
Date
2015-12
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Authors
de Dios Caballero, J ; Pastor, MD ; Vindel, A ; Máiz, L ; Yagüe, G ; Salvador, C ; Cobo, M ; Morosini, MI ; del Campo, R ; Cantón, R
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Publisher
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Genética y Microbiología
DOI
https://doi.org/10.1128/aac.02067-15
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info:eu-repo/semantics/article
Description
Abstract
Resistance to linezolid (LZD) in methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients with cystic fibrosis (CF) is due mainly to ribosomal mutations. We report on four CF patients with LZD-resistant MRSA bronchopulmonary infections by strains carrying the cfr gene. Strains from one patient also harbored the G2576U mutation (23S rRNA) and the G139R substitution (L3 protein). All strains belonged to the epidemic clone ST125 MRSA IVc. Our results support the monitoring of LZD resistance emergence in CF and non-CF MRSA isolates
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cfr-mediated linezolid resistance cystic fibrosis
Citation
Antimicrob Agents Chemother. 2015. 60(3):1878-82
URI
http://hdl.handle.net/10201/138122
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