Publication: Prognostic index expression of cyclin-D1, cerbB-2 and VEGF metastases vs corresponding primary cancers and metastatic vs non-metastatic adenocarcinomas
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Date
2008
Authors
Roger Parra, Edwin ; Young Park, Ji ; Midori Saito, Dalva ; Yae Takagaki, Teresa ; Ribeiro Rodrigues, Olavo ; Capelozzi, Vera Luiza
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The prognostic relevance of different
molecular markers in lung cancer is a crucial issue still
worth investigating, and the specimens collected and
analyzed represent a valuable source of material. Cyclin-
D1, c-erbB-2 and vascular endothelial growth factor
(VEGF) have shown to be promising as prognosticators
in human cancer. In this study, we sought to examine the
importance of Cyclin-D1, c-erbB-2 and VEGF, and to
study the quantitative relationship among these factors
and disease progression in metastases vs corresponding
primary cancer, and metastatic vs non metastatic
cancers. Material and Methods: We used
immunohistochemistry and morphometric analysis to
evaluate the amount of tumour staining for Cyclin-D1, cerbB-
2 and VEGF in 52 patients with surgically excised
ademocarcinoma of the lung, and the outcome for our
study was survival time until death from hematogenic
metastases. Results: Metastasis presented lower c-erbB-2
expression than corresponding primary cancers (p=0.02).
Cyclin-D1 and VEGF expression were also lower in
metastases than in corresponding primary cancers, but
this difference did not achieve statistical significance. Non-metastatic cancers also presented significantly
lower Cyclin-D1 and c-erbB-2 expression than
metastatic cancers (p<0.01 and p<0.01, respectively).
Equally significant was the difference between higher cerbB-
2 expression by metastatic cancers compared to
non-metastatic cancers (p=0.02). Considering survival in
Kaplan-Maier analysis, Cyclin-D1 (p=0.04), c-erbB-2
(p=0.04) and VEGF (p<0.01) were important predictors
of survival in metastatic cancers.
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