lnitiation and post-initiation chemopreventive 
effects of O-carotene in toad liver carcinogenesis

Publication:
lnitiation and post-initiation chemopreventive effects of O-carotene in toad liver carcinogenesis

dc.contributor.author	Sadek, I.A.	es
dc.contributor.author	Hayat, L.G.	es
dc.date.accessioned	2011-02-22T10:32:35Z
dc.date.available	2011-02-22T10:32:35Z
dc.date.issued	1996
dc.description.abstract	Hepatocellular carcinoma were recognized in the toad, Blfo iliridis, in 14 cases out of 50 by injection of 1 mg 7,12 dimethylbenz(a)anthracene (DMBA)/toad twicelweek for 12 weeks. In contrast, toads treated with DMB at the same dose level and B-carotene (BC), 0.05 mg (3 hr prior to the carcinogen)/toad, twicelweek for 12 weeks showed no tumor incidence. However, BC at the same dose level was less effective when administered 3 hr. after the carcinogen (DMBA). In 8 cases out of 50 cases neither tumor growth nor neoplastic changes were observed in toads treated with BC alone or olive oil. It is concluded that BC completely blocked hepatocarcinogenesis in toads when given 3 hr. before initiation.	es
dc.format	application/pdf	es
dc.format.extent	4	es
dc.identifier.issn	0213-3911	es
dc.identifier.uri	http://hdl.handle.net/10201/18846
dc.language	eng	es
dc.publisher	Murcia : F. Hernández	es
dc.relation.ispartof	Histology and histopathology	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Toads	es
dc.subject	B carotene	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina	es
dc.title	lnitiation and post-initiation chemopreventive effects of O-carotene in toad liver carcinogenesis	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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