Publication: lnitiation and post-initiation chemopreventive
effects of O-carotene in toad liver carcinogenesis
Authors
Sadek, I.A. ; Hayat, L.G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Hepatocellular carcinoma were recognized in
the toad, Blfo iliridis, in 14 cases out of 50 by injection
of 1 mg 7,12 dimethylbenz(a)anthracene (DMBA)/toad
twicelweek for 12 weeks. In contrast, toads treated with
DMB at the same dose level and B-carotene (BC), 0.05
mg (3 hr prior to the carcinogen)/toad, twicelweek for 12
weeks showed no tumor incidence. However, BC at the
same dose level was less effective when administered
3 hr. after the carcinogen (DMBA). In 8 cases out of 50
cases neither tumor growth nor neoplastic changes were
observed in toads treated with BC alone or olive oil. It is
concluded that BC completely blocked hepatocarcinogenesis
in toads when given 3 hr. before
initiation.
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Citation
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