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How is plasminogen/plasmin system contributing to regulate sperm entry into the oocyte?

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dc.contributor.advisorCoy Fuster, Pilar
dc.contributor.authorGrullón LA
dc.contributor.authorGadea Mateos, Joaquín
dc.contributor.authorMondéjar Corbalán, Irene
dc.contributor.authorRomar Andrés, Raquel
dc.contributor.authorMatas Parra, Carmen
dc.contributor.authorCoy Fuster, Pilar
dc.contributor.departmentFisiología
dc.contributor.otherFacultades de la UMU
dc.date.accessioned2026-03-30T10:56:49Z
dc.date.available2026-03-30T10:56:49Z
dc.date.copyright©The Author(s) 2013
dc.date.issued2013-12-30
dc.description.abstractPlasminogen is present in the oviduct, on the zona pellucida (ZP) and on oolemma, and reduces the number of sperm penetrating the oocyte during in vitro fertilization in pig and cow. It is unknown how this reduction occurs. We tested whether plasminogen (1) changed the ZP resistance to enzymatic digestion thus making the passage of the spermatozoa across it difficult; (2) reduced the sperm functionality, assessed by sperm viability, motility, spontaneous acrosome reaction and membrane lipid disorder; or (3) affected the sperm-ZP binding before or after sperm-ZP interaction. The mechanism by which plasminogen/plasmin system contributes to regulate sperm entry into the oocyte is not inducing a ZP hardening or a decrease in sperm functionality but detaching more than 50% of sperm bound to the ZP. It is suggested that the fertilizing spermatozoon activates plasminogen into plasmin at the oocyte surface and that plasmin removes additional spermatozoa attached to the ZP.
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dc.identifier.citationGrullón LA, Gadea J, Mondéjar I, Matás C, Romar R, Coy P. How is plasminogen/plasmin system contributing to regulate sperm entry into the oocyte? Reprod Sci. 2013 Sep;20(9):1075-82. doi: 10.1177/1933719112473657. Epub 2013 Feb 18. PMID: 23420828; PMCID: PMC3745708.
dc.identifier.doi10.1177/1933719112473657
dc.identifier.eissn1933-7205
dc.identifier.urihttp://hdl.handle.net/10201/224241
dc.languageeng
dc.relationSpanish Ministry of Science and Innovation and FEDER, Grant AGL2009-12512-C02-01.
dc.relation.publisherversionhttps://link.springer.com/article/10.1177/1933719112473657
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectIVF
dc.subjectSperm-zona pellucida binding
dc.subjectPolyspermy
dc.subjectPlasmin
dc.subjectPlasminogen
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleHow is plasminogen/plasmin system contributing to regulate sperm entry into the oocyte?
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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