Publication: Mammary myofibroblastoma: an update with emphasis on the most diagnostically challenging variants
Authors
Magro, Gaetano
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
10.14670/HH-11-658
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info:eu-repo/semantics/article
Description
Abstract
Myofibroblastoma (MFB) is a rare benign
mesenchymal tumor which usually occurs in the breast
parenchyma of both females and males. Although this
tumor is typically composed of bland-looking spindleshaped cells arranged in short fascicles interrupted by
keloidal-like collagen fibers, several variations on this
basic morphological theme do exist. With the advent of
mammographic screening, an increased number of
mammary MFBs are being detected and pathologists
should be aware of the wide morphological and
immunohistochemical spectrum exhibited by this
unusual tumor. This review focuses on the most
diagnostically challenging variants of mammary MFB,
which could represent potential diagnostic pitfalls of
malignancy, especially when evaluating needle core
biopsies. In this regard the following variants of MFB,
including the most recently recognized, will be
presented: myxoid MFB, lipomatous MFB, epithelioid
cell MFB, deciduoid cell MFB, epithelioid cell MFB
with multinodular growth pattern, palisaded/
schwannian-like MFB and MFB with extensive myxoedematous stromal changes. Histological illustrations
along with differential diagnostic problems for each
single variant of MFB will be provided to offer helpful
suggestions for a correct diagnostic approach in daily
practice.
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Citation
Histology and Histopathology, vol.31, nÂş 1, (2016)
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