Publication: Anti-death strategies against oxidative stress in grafted mesenchymal stem cells
Authors
Woochul, Chang ; Byeong-Wook, Song ; Jae-Youn, Moon ; Min-Ji, Cha ; Onju, Ham ; Se-Yeon, Lee ; Eunmi, Choi ; EunHyum, Choi ; Ki-Chul, Hwang
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Mesenchymal stem cells (MSCs) possess the
potential for use in cell-based therapy for repair of
myocardial injury. The therapeutic potential of MSCs is
based on the capacity of MSCs to differentiate into
cardiac tissue and release paracrine factors. However, a
major problem in the clinical application of MSC-based
therapy is the poor viability of transplanted MSCs at the
site of graft due to harsh microenvironment conditions,
such as ischemia and/or anoikis. Ischemia after
myocardial infarction (MI) and interaction of MSCs with
their niche is associated with increased production of
reactive oxygen species (ROS). ROS hinder cell
adhesion and induce detachment of cells, which induces
anoikis signals in implanted MSCs. Therefore, strategies
to regulate oxidative stress following the implantation of
MSCs are therapeutically attractive. In this review, we
first describe ROS as a major obstacle in MSC-based
therapy and focus on manipulation of implanted MSCs
to reduce ROS-mediated anoikis.
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Citation
Histology and Histopathology, vol. 28, nº 12 (2013)
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