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Small cell carcinoma of the urinary bladder

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dc.contributor.authorPant-Purohit, Muktaes
dc.contributor.authorLópez Beltrán, Antonioes
dc.contributor.authorMontironi, Rodolfo
dc.contributor.authorMacLennan, Gregory T.
dc.contributor.authorCheng, Lian
dc.date.accessioned2015-01-20T12:06:09Z
dc.date.available2015-01-20T12:06:09Z
dc.date.issued2010
dc.description.abstractSmall cell carcinoma of the urinary bladder(SCCUB) is a rare and aggressive cancer of the bladder.SCCUB is part of neuroendocrine family of tumors thataffect several organ systems including respiratory,gastrointestinal and male and female genitourinary tract.SCCUB affect males predominantly with common riskfactors include smoking, bladder calculi, bladdermanipulation, and chronic cystitis. Prognosis of SCCUBremains poor due to high metastatic potential and lack ofsymptoms in earlier stages of the disease. Pathogenesisof the disease is linked to loss of genetic material,hypermethylation of tumor suppressors and at timesamplification of the chromosomal regions carryingoncogenes. Majority of cases are treated with localresection of the tumor with neoadjuvant or adjuvantplatinum-based chemotherapy regimen. Radiationtherapy is used as alternative to radical cystectomy or aspalliative measure. This article provides epidemiology,molecular pathogenesis, histochemistry, and currentmanagement options for SCCUB. Furthermore wereviewed all recent studies involving advancement intargeted molecular therapy for neuroendocrine tumors.en_EN
dc.formatapplication/pdfes
dc.format.extent5es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/42581
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectUrinary bladderes
dc.subjectMolecular geneticses
dc.subject.other616.6 - Patología del sistema genitourinarioes
dc.titleSmall cell carcinoma of the urinary bladderes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25, nº2 (2010)