Pigment epithelium-derived factor protects retinal pigment epithelial cells against cytotoxicity “in vitro”

Nadal-Nicolás, Francisco Manuel; Becerra, S. Patricia

Publication:
Pigment epithelium-derived factor protects retinal pigment epithelial cells against cytotoxicity “in vitro”

dc.contributor.author	Nadal-Nicolás, Francisco Manuel
dc.contributor.author	Becerra, S. Patricia
dc.contributor.department	Oftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
dc.contributor.other	Facultad de Medicina
dc.date.accessioned	2026-01-27T19:32:46Z
dc.date.available	2026-01-27T19:32:46Z
dc.date.copyright	© 2018, Springer International Publishing AG, part of Springer Nature
dc.date.issued	2018-05-03
dc.description.abstract	Oxidative stress has been implicated in neurodegenerative diseases, such as age-related macular degeneration. Hydrogen peroxide and sodium iodate can mediate oxidative injury. Sodium iodate induces a selective retinal degeneration targeting the RPE. We describe a method of chronic sodium iodate-mediated injury on RPE cells that may serve to evaluate protective factors against oxidative stress. Cytotoxicity and cell viability curves of ARPE-19 cells with sodium iodate were generated. The antioxidant pigment epithelium-derived factor decreased sodium iodate-mediated cytotoxicity without affecting ARPE-19 cell viability. A cell culture system to evaluate protection against oxidative stress injury with PEDF is discussed.
dc.format	application/pdf
dc.format.extent	8
dc.identifier.citation	Adv Exp Med Biol. 2018;1074:457-464
dc.identifier.doi	https://doi.org/10.1007/978-3-319-75402-4_56
dc.identifier.eisbn	978-3-319-75402-4
dc.identifier.isbn	978-3-319-75401-7
dc.identifier.uri	http://hdl.handle.net/10201/195290
dc.language	eng
dc.publisher	Springer Nature.
dc.relation	This work was supported by the NEI, NIH Intramural Research Program.
dc.relation.ispartof	Advances in Experimental Medicine and Biology. Ed.: Springer New York LLC, pp. 457-464
dc.relation.publisherversion	https://link.springer.com/chapter/10.1007/978-3-319-75402-4_56
dc.rights.accessRights	info:eu-repo/semantics/restrictedAccess
dc.subject	Pigment epithelium-derived factor (PEDF)
dc.subject	Retinal pigment epithelium (RPE)
dc.subject	ARPE-19 cells
dc.subject	Toxicity
dc.subject	Oxidative stress
dc.subject	Sodium iodate (NaIO3)
dc.subject	Viability
dc.subject	Age-related macular degeneration
dc.subject.ods	Objetivo 3: Salud
dc.title	Pigment epithelium-derived factor protects retinal pigment epithelial cells against cytotoxicity “in vitro”
dc.type	info:eu-repo/semantics/bookPart
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