Publication:
Pigment epithelium-derived factor protects retinal pigment epithelial cells against cytotoxicity “in vitro”

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Nadal-Nicolás (RetDegDis 2018) Chapter56_PEDF protects RPE.pdf(450.72 KB)
Date
2018-05-03
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Authors
Nadal-Nicolás, Francisco Manuel ; Becerra, S. Patricia
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Facultad de Medicina
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Publisher
Springer Nature.
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Oftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
DOI
https://doi.org/10.1007/978-3-319-75402-4_56
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info:eu-repo/semantics/bookPart
Description
Abstract
Oxidative stress has been implicated in neurodegenerative diseases, such as age-related macular degeneration. Hydrogen peroxide and sodium iodate can mediate oxidative injury. Sodium iodate induces a selective retinal degeneration targeting the RPE. We describe a method of chronic sodium iodate-mediated injury on RPE cells that may serve to evaluate protective factors against oxidative stress. Cytotoxicity and cell viability curves of ARPE-19 cells with sodium iodate were generated. The antioxidant pigment epithelium-derived factor decreased sodium iodate-mediated cytotoxicity without affecting ARPE-19 cell viability. A cell culture system to evaluate protection against oxidative stress injury with PEDF is discussed.
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Pigment epithelium-derived factor (PEDF) , Retinal pigment epithelium (RPE) , ARPE-19 cells , Toxicity , Oxidative stress , Sodium iodate (NaIO3) , Viability , Age-related macular degeneration
Citation
Adv Exp Med Biol. 2018;1074:457-464
URI
http://hdl.handle.net/10201/195290
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