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New insights into the function of noncoding RNA and its potential role in disease pathogenesis

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dc.contributor.authorAskew, D.S.es
dc.contributor.authorXu, F.es
dc.date.accessioned2011-02-22T11:07:42Z
dc.date.available2011-02-22T11:07:42Z
dc.date.issued1999
dc.description.abstractAll polyadenylated RNAs expressed in mammalian tissues are assumed to be transported to the cytoplasm where they direct the synthesis-of a protein product. This mainstream view of the function of p~lyaden~latetrda nscripts is currently being challenged by the identification of a novel class of genes which, although they encode polyadenylated RNA, do not make a translated protein. Many of these noncoding RNAs are developmentally regulated or show highly restricted patterns of gene expression, and their functions are providing important insight into RNA-based mechanisms of gene expression, genomic imprinting, cell cycle progression, and differentiation. The purpose of this review is to discuss the current understanding of mammalian noncoding RNAs, and to highlight their potential for identifying new pathways of human disease.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19145
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectNoncodinges
dc.subjectRNAes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleNew insights into the function of noncoding RNA and its potential role in disease pathogenesises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.14, nº 1 (1999)