Publication: New insights into the function of noncoding RNA and its potential role in disease pathogenesis
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Date
1999
Authors
Askew, D.S. ; Xu, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
All polyadenylated RNAs expressed in
mammalian tissues are assumed to be transported to the
cytoplasm where they direct the synthesis-of a protein
product. This mainstream view of the function of
p~lyaden~latetrda nscripts is currently being challenged
by the identification of a novel class of genes which,
although they encode polyadenylated RNA, do not make
a translated protein. Many of these noncoding RNAs are
developmentally regulated or show highly restricted
patterns of gene expression, and their functions are
providing important insight into RNA-based mechanisms
of gene expression, genomic imprinting, cell cycle
progression, and differentiation. The purpose of
this review is to discuss the current understanding of
mammalian noncoding RNAs, and to highlight their
potential for identifying new pathways of human
disease.
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