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Scanning electron microscopy of human and murine melanoma cells exposed to medium chain-length, C6mC,2d i carboxylic acids in tissue culture

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dc.contributor.authorBreathnach, A. S.es
dc.contributor.authorRobins, E. J.es
dc.contributor.authorBhasin, Y. P.
dc.contributor.authorEthridge, L. B.
dc.contributor.authorNazzaro-Porro, M.
dc.contributor.authorPassi, S.
dc.contributor.authorPicardo, M.
dc.date.accessioned2011-01-17T12:40:07Z
dc.date.available2011-01-17T12:40:07Z
dc.date.issued1987
dc.description.abstractHuman and murine (Harding-Passey and Cloudman) melanoma cells were exposed to various concentrations (1 X 10-3M-l X 10-lM) of adipic (C,), azelaic (C,), and dodecanedioic (C,,) acids for 1-6 hours in tissue culture, and the effects on shape and surface topography were examined by scanning electron microscopy. Effects, i.e., rounding up, concentration of microvilli, blebbing, and prominence of retraction fibrils were time and dose dependent, and for the same concentrations and exposure times, C,, had a greater effect than C,, and both a significantly greater effect than C,. These differential reactions to the three diacids parallel previously reported effects on cell kinetics and viability. The changes could be due to a prime effect on the cell membrane, or they might reflect phases of the cell cycle directed by action of the diacids on the nucleus; this latter seems unlikely. An effect on the cytoskeleton is possibly involved.
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/17880
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMelanomaes
dc.subjectDicarboxylic acidses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.5 - Piel. Dermatología clínicaes
dc.titleScanning electron microscopy of human and murine melanoma cells exposed to medium chain-length, C6mC,2d i carboxylic acids in tissue culturees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 2, nº 3 (1987)