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Cut-off value for β-trace protein (β-TP) as a rapid diagnostic of cerebrospinal fluid (CSF) leak detection

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dc.contributor.authorAlmela, María Teresa
dc.contributor.authorNavarro Zaragoza, Javier
dc.contributor.authorLaorden Carrasco, María Luisa
dc.contributor.authorSánchez Celemín, Fernando Javier.
dc.contributor.authorAlmela Rojo, Pilar
dc.contributor.departmentFarmacología
dc.date.accessioned2026-03-27T12:34:09Z
dc.date.available2026-03-27T12:34:09Z
dc.date.copyright© 2023 The Authors
dc.date.issued2023-08-08
dc.description.abstractObjective: To find an adequate cut-off point for beta trace protein (β-TP) in nasal secretion (NS) and validate this diagnostic test with a large sample of patients. Likewise, we evaluated β-TP test efficacy to confirm the cerebrospinal fluid (CSF) leakage closure after treatment. Methods: We performed a retrospective analysis with 207 samples from 162 patients with suspected CSF leakage received in the Hospital Universitario Virgen de la Arrixaca between 2010 and 2016. Twenty-five samples were included in the control group. Samples were obtained from NS through a swab to determine β-TP using a nephelometry-based assay. Sensitivity, specificity, and area under the curve (AUC) for β-TP in NS were assessed using the receiver operator characteristic (ROC) analysis. Results: Using imaging techniques, the diagnosis of CSF leak was confirmed in 57 patients (35.19%), while 105 had a negative diagnosis (64.81%). Patients with CSF leakage had significantly higher β-TP values in NS (16.07 ± 16.94 mg/L, p < .001) than the control group (0.33 ± 0.12 mg/L) and patients without CSF leakage (0.61 ± 2.34 mg/L). Applying a 1 mg/L cut-off point resulted in 96.5% sensitivity and 97.1% specificity. Positive and negative predictive values (PPV and NPV) at this cut-off were 94.9% and 98.6%, respectively. Finally, this cutoff point yields a test efficacy for CSF leak diagnosis of 97% (95% CI 92.9–98.9). Conclusion: Our study has established a 1 mg/L β-TP concentration in NS as a cutoff point for CSF leakage diagnosis with high sensibility and specificity. These results suggest that β-TP analysis could be useful to check CSF leak resolution.
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dc.identifier.citationAlmela M-T, Navarro-Zaragoza J, Laorden M-L, Sánchez-Celemín F, Almela P. Cut-off value for β-trace protein (β-TP) as a rapid diagnostic of cerebrospinal fluid (CSF) leak detection. Laryngoscope Investigative Otolaryngology. 2023;1‐7. doi:10.1002/lio2.1150
dc.identifier.doi10.1002/lio2.1150
dc.identifier.issn2378-8038
dc.identifier.urihttp://hdl.handle.net/10201/223682
dc.languageeng
dc.publisherWiley
dc.relationFundación Séneca, Grant/Award Number: 20847/PI/18
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectβ-trace protein
dc.subjectNephelometry
dc.subjectCut-off
dc.subjectCerebrospinal fluid leakage
dc.subjectRhinorrea
dc.subject.odsObjetivo 3: Salud
dc.titleCut-off value for β-trace protein (β-TP) as a rapid diagnostic of cerebrospinal fluid (CSF) leak detection
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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relation.isAuthorOfPublicationa28169ff-757a-4fa6-a2c9-687ece58e422
relation.isAuthorOfPublicatione77685fe-1963-4aa6-a833-5b77517d314b
relation.isAuthorOfPublication5028b798-617b-4311-8389-11b8f71ac210
relation.isAuthorOfPublication.latestForDiscovery91a9c0cf-0115-4c34-9b53-72a417c2d883
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