Publication: Cut-off value for β-trace protein (β-TP) as a rapid diagnostic of cerebrospinal fluid (CSF) leak detection
Loading...
Date
2023-08-08
Authors
Almela, María Teresa ; Navarro Zaragoza, Javier ; Laorden Carrasco, María Luisa ; Sánchez Celemín, Fernando Javier. ; Almela Rojo, Pilar
item.page.secondaryauthor
item.page.director
Publisher
Wiley
publication.page.editor
publication.page.department
DOI
10.1002/lio2.1150
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Objective: To find an adequate cut-off point for beta trace protein (β-TP) in nasal
secretion (NS) and validate this diagnostic test with a large sample of patients. Likewise,
we evaluated β-TP test efficacy to confirm the cerebrospinal fluid (CSF) leakage
closure after treatment.
Methods: We performed a retrospective analysis with 207 samples from 162 patients
with suspected CSF leakage received in the Hospital Universitario Virgen de la Arrixaca
between 2010 and 2016. Twenty-five samples were included in the control
group. Samples were obtained from NS through a swab to determine β-TP using a
nephelometry-based assay. Sensitivity, specificity, and area under the curve (AUC)
for β-TP in NS were assessed using the receiver operator characteristic (ROC)
analysis.
Results: Using imaging techniques, the diagnosis of CSF leak was confirmed in
57 patients (35.19%), while 105 had a negative diagnosis (64.81%). Patients with
CSF leakage had significantly higher β-TP values in NS (16.07 ± 16.94 mg/L,
p < .001) than the control group (0.33 ± 0.12 mg/L) and patients without CSF
leakage (0.61 ± 2.34 mg/L). Applying a 1 mg/L cut-off point resulted in 96.5%
sensitivity and 97.1% specificity. Positive and negative predictive values (PPV
and NPV) at this cut-off were 94.9% and 98.6%, respectively. Finally, this cutoff
point yields a test efficacy for CSF leak diagnosis of 97% (95% CI
92.9–98.9).
Conclusion: Our study has established a 1 mg/L β-TP concentration in NS as a cutoff
point for CSF leakage diagnosis with high sensibility and specificity. These results
suggest that β-TP analysis could be useful to check CSF leak resolution.
publication.page.subject
Citation
Almela M-T, Navarro-Zaragoza J,
Laorden M-L, Sánchez-Celemín F, Almela P. Cut-off value for
β-trace protein (β-TP) as a rapid diagnostic of cerebrospinal
fluid (CSF) leak detection. Laryngoscope Investigative
Otolaryngology. 2023;1‐7. doi:10.1002/lio2.1150
item.page.embargo
Collections
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/