Publication: Role of multipotent fibroblasts in the healing colonic mucosa of rabbits. Ultrastructural and immunocytochemical study
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Date
1992
Authors
Mori, Naoki ; Doi, Y. ; Hara, K. ; Yoshizuka, M. ; Ohsato, K. ; Fujimoto, Sunao
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Light- and electron microscopy and
immunocytochemistry were used to study the healing
colonic mucosa of rabbits after experimental excision.
Between 3 and 5 days, abundant young fibroblasts
which retained many features of mesenchymal cells
invaded the growing capillaries into the loose connective
tissue of the healing colonic mucosa. Our electron
microscopy revealed the transformation of these young
fibroblasts into smooth muscle cells, into histiocyte-like
cells involved in phagocytotic activity, and into
vasoformative cells incorporated into the growing
capillaries. The mitotic proliferation of pre-existing
smooth muscle cells at the ulcer margin did not seem to
be the major reason for re-establishment of the muscular
tissue.
The present immunocytochemistry revealed an active
production of fibronectin in rough endoplasmic
reticulum in the young fibroblasts. This may mean that
this glycoprotein is involved in the re-establishment of
both connective and muscular tissues by enhancement of
adhesion and chemoattractant activities of such cells. In
addition, the immunoreaction of endothelial celis of the
growing capillaries suggests a role of this glycoprotein
in the acceleration of the neocapillarization.
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