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Expression of Histone Deacetylases 1, 2 and 3 in histological subtypes of testicular germ cell tumours

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dc.contributor.authorFritzsche, Florian R.
dc.contributor.authorHasler, Anja
dc.contributor.authorBode, Peter K.
dc.contributor.authorAdams, Heiner
dc.contributor.authorSeifert, Hans H.
dc.contributor.authorSulser, Tullio
dc.contributor.authorMoch, Holger
dc.contributor.authorBarghorn, André
dc.contributor.authorKristiansen, Glen
dc.date.accessioned2016-05-03T17:31:51Z
dc.date.available2016-05-03T17:31:51Z
dc.date.issued2011
dc.description.abstractIn this study we aimed to evaluate the protein expression of class I histone deacetylases (HDAC) in testicular germ cell tumours (GCT) and to analyse differences between the histological subtypes of testicular GCT. 325 testicular GCT were included in a tissue microarray with each histological subtype of the tumour being separately represented on this array. Expression of class I HDAC isoforms 1, 2 and 3 was assessed by immunohistochemistry. While HDAC2 and 3 were highly expressed in all histological subtypes of GCT, HDAC1 was almost consistently expressed at lower levels. We observed significant differences in the expression of the respective HDACs between seminoma and non-seminoma GCT tissue components. Interestingly, choriocarcinomas showed generally high expression values for all three class I HDAC isoforms. Relevant correlations with clinicopathological parameters could not be demonstrated. Contrasting published findings on other tumour entities, no immediate practical diagnostic or prognostic value for HDAC1-3 in GCT could be inferred. However, the high expression levels might still be indicative for a treatment response to HDAC inhibitors which ought to be evaluated in further studies.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/49531
dc.languageenges
dc.publisherF. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología.es
dc.relation.ispartofHistology and histopathology, Vol. 26, nº12 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectHDACes
dc.subjectImmunohistochemistryes
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleExpression of Histone Deacetylases 1, 2 and 3 in histological subtypes of testicular germ cell tumourses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26,nº12 (2011)