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Usefulness of HPV testing in the follow-up of untreated cervical low grade lesions

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dc.contributor.authorClavel, C.es
dc.contributor.authorBory, J.P.es
dc.contributor.authorCaudroy, S.
dc.contributor.authorLorenzato, M.
dc.contributor.authorDurlach, A.
dc.contributor.authorGraesslin, O.
dc.contributor.authorQuereux, C.
dc.contributor.authorBirembaut, P.
dc.date.accessioned2011-06-30T12:01:25Z
dc.date.available2011-06-30T12:01:25Z
dc.date.issued2005
dc.description.abstractThe aim of the present work was to evaluate the usefulness of high-risk human papillomavirus (HRHPV) testing for the follow-up of women with untreated low grade cervical squamous cell lesions (LSIL). For that, 412 women with a cytological diagnosis of LSIL at entry were monitored by cytology, HR-HPV testing with the Hybrid Capture II assay (HC-II) and colposcopy. Our primary endpoint was clinical progression defined by the presence of a high grade cervical intraepithelial neoplasia (CIN2 and CIN3) at the biopsy. At baseline, histological control revealed 10 CIN2 and 11 CIN3 only in the cohort of women HR-HPV+. In the follow-up, 4 CIN2 and 8 CIN3 were detected, always in the women initially HR-HPV+. Thus, the recurrence of a HR-HPV+ infection clearly selects a population at high-risk for CIN2-3. The semi-quantitative appreciation of the viral load with HC-II could not be used as a good prognostic factor for the follow-up of women with LSIL. HR-HPV testing reduces the number of cytology and colposcopy examinations in the follow-up of women aged >35 years when HPV testing is initially negative. Thus HR-HPV testing should be reserved for the follow-up of this population of women initially HR-HPV+ and proposed 6 to 12 months after the cytological diagnosis of LSIL.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22567
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCervical intraepithelial neoplasiaes
dc.subjectHuman papillomaviruses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::618 - Ginecología. Obstetriciaes
dc.titleUsefulness of HPV testing in the follow-up of untreated cervical low grade lesionses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.20, nº 4 (2005)