Publication: Usefulness of HPV testing in the follow-up of untreated cervical low grade lesions
Authors
Clavel, C. ; Bory, J.P. ; Caudroy, S. ; Lorenzato, M. ; Durlach, A. ; Graesslin, O. ; Quereux, C. ; Birembaut, P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The aim of the present work was to evaluate
the usefulness of high-risk human papillomavirus (HRHPV)
testing for the follow-up of women with untreated
low grade cervical squamous cell lesions (LSIL). For
that, 412 women with a cytological diagnosis of LSIL at
entry were monitored by cytology, HR-HPV testing with
the Hybrid Capture II assay (HC-II) and colposcopy. Our
primary endpoint was clinical progression defined by the
presence of a high grade cervical intraepithelial
neoplasia (CIN2 and CIN3) at the biopsy. At baseline,
histological control revealed 10 CIN2 and 11 CIN3 only
in the cohort of women HR-HPV+. In the follow-up, 4
CIN2 and 8 CIN3 were detected, always in the women
initially HR-HPV+. Thus, the recurrence of a HR-HPV+
infection clearly selects a population at high-risk for
CIN2-3. The semi-quantitative appreciation of the viral
load with HC-II could not be used as a good prognostic
factor for the follow-up of women with LSIL. HR-HPV
testing reduces the number of cytology and colposcopy
examinations in the follow-up of women aged >35 years
when HPV testing is initially negative. Thus HR-HPV
testing should be reserved for the follow-up of this
population of women initially HR-HPV+ and proposed 6
to 12 months after the cytological diagnosis of LSIL.
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