Publication: Renal leiomyoma: An immunohistochemical, ultrastructural and comparative genomic hybridization study
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Date
2007
Authors
Kuroda, Naoto ; Inoue, Y. ; Taguchi, T. ; Tominaga, A. ; Hes, O. ; Michal, Michal ; Hayashi, Yoshihiro ; Hiroi, Makoto ; Shuin, T. ; Lee, Gang-Hong
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Renal leiomyoma is a rare neoplasm. We
report such a case in a 57-year-old Japanese woman who
was found to have a mass in the left kidney. The
histological examination disclosed the proliferation of
spindle cells showing a benign appearance. Entrapped
tubular cells were observed in the peripheral area of the
tumor. The immunohistochemical examination of
spindle neoplastic cells showed a positive reaction for
alpha smooth muscle actin, h-caldesmon, l-caldesmon,
calponin, muscle actin, myosin and desmin.
Additionally, the ultrastructural examination of the
tumor showed membrane caveolae and myofilaments in
the cytoplasm. This tumor was considered to show a
differentiation into smooth muscle cells. The
comparative genomic hybridization of the tumor
detected the combined losses of chromosomes 4, 6, 12
and 14 which has not been previously described in renal
tumors. Finally, the immunohistochemical panel of
smooth muscle markers and ultrastructural and genetic
study may be useful in diagnosing renal leiomyoma.
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