Publication: Experimental models for carcinogenesis in
the house musk shrew, Suncus murinus, lnsectivora
Authors
Tsubura, A. ; Shikata, N. ; Oyaizu, T. ; Takahashi, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Animal carcinogenicity studies have niainly
been performed on rodents. From the phylogenetic point
of view, animals closer to humans must be included in
these studies. lnsectivora are considered to be the most
prirnitive placental mammals and much closer to the
early primates than rodents. Among the insectivora, the
house musk shrew (Suncus mul-inus, family Soracidae),
has been bred under laboratory condition. This animal is
small having a short life span, and a comparatively low
incidence of spontaneous tumor provides a useful animal
model for tumor induction studies. We have examined
the carcinogenicity of severa1 chemicals known to
produce tumors in rodents and found shrews: in general,
to be sensitive to these chemicals but often showed
different targets compared to rodents, and some
chemicals tested were demonstrated not to be
carcinogenic. Here we describe the carcinogenic studies
performed in our laboratory and review other works
including the occurrence of spontaneous tumors in
shrews. Shrew carcinogenesis may fill up the gap of
knowledge existing between the rodents and hurnan
beings.
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Citation
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