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Lactylation formation, gene regulation, biological functions, and clinical relevance

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dc.contributor.authorZhimei Qiu
dc.contributor.authorYouyang Huang
dc.contributor.authorQing Guo
dc.contributor.authorYing Li
dc.contributor.authorYongchao Zhao
dc.contributor.authorBei Shi
dc.contributor.authorXiaoyu Wei
dc.contributor.departmentBiología Celular e Histología
dc.contributor.editorUniversidad de Murcia, Departamento de Biologia Celular e Histiologia
dc.date.accessioned2026-03-23T09:41:02Z
dc.date.available2026-03-23T09:41:02Z
dc.date.issued2026
dc.description.abstractLactate, as an end-product of glycolysis, has been considered as a metabolic waste that participates in a few physiological functions. Recently, a novel study by Zhao’s laboratory reported that lactate can serve as an epigenetic modification substrate, causing histone or nonhistone lysine residues to undergo lactylation, which then regulates gene transcription, translation, and protein function. Subsequent studies confirmed that lactylation plays an important role in a series of physiological and pathological processes, such as inflammation, cancer, and other biological processes. In this review, we summarize advanced achievements on the effects of lactylation in various diseases and potential treatment targets, providing a reference and direction for future research.
dc.formatapplication/pdf
dc.format.extent15
dc.identifier.doihttps://doi.org/10.14670/HH-18-980
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/222001
dc.languageeng
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEpigenetics
dc.subjectPost-translational modifications
dc.subjectLactylation
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleLactylation formation, gene regulation, biological functions, and clinical relevance
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology, Vol.41, Nº4, (2026)