Publication: Lactylation formation, gene regulation, biological functions, and clinical relevance
Authors
Zhimei Qiu ; Youyang Huang ; Qing Guo ; Ying Li ; Yongchao Zhao ; Bei Shi ; Xiaoyu Wei
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Publisher
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Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-980
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info:eu-repo/semantics/article
Description
Abstract
Lactate, as an end-product of glycolysis, has
been considered as a metabolic waste that participates in
a few physiological functions. Recently, a novel study by
Zhao’s laboratory reported that lactate can serve as an
epigenetic modification substrate, causing histone or
nonhistone lysine residues to undergo lactylation, which
then regulates gene transcription, translation, and protein
function. Subsequent studies confirmed that lactylation
plays an important role in a series of physiological and
pathological processes, such as inflammation, cancer,
and other biological processes. In this review, we
summarize advanced achievements on the effects of
lactylation in various diseases and potential treatment
targets, providing a reference and direction for future
research.
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Citation
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