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Birth defects in juvenile Wistar rats after exposure to immunosuppressive drugs during pregnancy

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dc.contributor.authorKabat Koperska, Joanna
dc.contributor.authorKolasa Wołosiuk, Agnieszka
dc.contributor.authorPilutin, Anna
dc.contributor.authorSafranow, Krzysztof
dc.contributor.authorKosik Bogacka, Danuta
dc.contributor.authorBaranowska Bosiacka, Irena
dc.contributor.authorGołembiewska, Edyta
dc.contributor.authorKędzierska, Karolina
dc.contributor.authorDomański, Leszek
dc.contributor.authorCiechanowski, Kazimierz
dc.date.accessioned2022-02-02T12:27:21Z
dc.date.available2022-02-02T12:27:21Z
dc.date.issued2017
dc.description.abstractIntroduction: Immunosuppressive drugs and their active metabolites can cross the placental barrier and enter fetal circulation. The adverse effects on the fetus include chromosomal aberrations, structural malformations, organ-specific toxicity and intrauterine growth retardation. The aim of our study was to investigate the impact of “safe” and “contraindicated” immunosuppressive drugs on birth defects in juvenile Wistar rats after exposure of pregnant female rats to these drugs. Material and methods: The study was conducted on 32 female Wistar rats, subjected to immunosuppressive regimens most commonly used in therapy of human kidney transplant recipients. The animals received drugs by oral gavage 2 weeks before pregnancy and during 3 weeks of pregnancy. Results: Treatment with mycophenolate mofetil and everolimus turned out to be toxic. We have noticed a significantly reduced number of live births in all pregnant rats exposed to these drugs in combination with calcineurin inhibitors and prednisone. Malformations and histological changes of fetal organs were confirmed after mycophenolate mofetil exposure during pregnancy. Conclusions: Mycophenolate mofetil turned out to be more toxic when used with tacrolimus than with cyclosporin (delivery of live offspring was possible only in the latter group). Everolimus in combination with cyclosporin effectively suppressed the fetal maturation in utero, but did not contribute to the development of malformations.es
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dc.format.extent13es
dc.identifier.citationHistology and Histopathology, Vol.32, nº1, (2017)
dc.identifier.doiDOI: 10.14670/HH-11-769
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/116670
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCongenital malformationes
dc.subjectRatses
dc.subjectPregnancyes
dc.subjectImmunosuppressive Drugses
dc.subjectTransplantationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleBirth defects in juvenile Wistar rats after exposure to immunosuppressive drugs during pregnancyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.32, nº1 (2017)