Publication: Prognostic significance of augmented metallothionein
(MT) expression correlated with Ki-67 antigen
expression in selected soft tissue sarcomas
Authors
Dziegiel, Piotr ; Salwa-Zurawska, W. ; Zurawski, J. ; Wojnar, A. ; Zabel, M.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
In soft tissue sarcomas, the most important
prognostic criteria include extent of malignancy (G), size
of the tumour and intensity of Ki-67 antigen expression.
In recent times expression of metallothionein (MT) in
cells of some malignant processes of epithelial origin
was found to correlate with intensity of Ki-67 antigen
expression and to carry a possible prognostic
significance. The present study aimed at a demonstration
of prognostic value of MT expression and at comparing
it with Ki-67 antigen expression and G grade in selected
soft tissue sarcomas. Immunohistochemical studies were
performed on paraffin sections in 54 cases of malignant
fibrous histiocytoma (MFH), 18 cases of liposarcoma
and 20 cases of synovial sarcoma. The extent of MT and
Ki-67 antigen expression was evaluated and an attempt
was made to correlate the results with each other and
with grade of the tumour. Expression of MT was evident
both in the cytoplasm and in cell nuclei of all studied
sarcomas. The most pronounced MT expression was
noted in MFH-type tumours. The extent of Ki-67 antigen
expression was similar in MFH and liposarcoma and was
the lowest in synovial sarcoma. In MFH, liposarcoma
and synovial sarcoma a pronounced positive correlation
was documented between expression of MT and Ki-67
antigen (r=0.85; p<0.001; r=0.93, p<0.0001; r=0.79,
p<0.0001). In all types of the tumours a positive relation
was detected between MT expression, expression of Ki-
67 and G grade of malignancy in the tumour. Moreover,
patients with higher MT expression in the studied
tumours demonstrated a shorter survival. MT expression
in soft tissue tumours of MFH, liposarcoma and synovial
sarcoma type strongly correlated with intensity of
proliferation (Ki-67) and G grade and could be useful in
defining the extent of malignancy and in prognostic
appraisal in the tumours.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.