Genes Encoding Mammalian Oviductal Proteins Involved in Fertilization are Subjected to Gene Death and Positive Selection

Fouchécourt, Sophie; Goudet, Ghylène; Monget, Philippe; Moros Nicolás, Carla

Publication:
Genes Encoding Mammalian Oviductal Proteins Involved in Fertilization are Subjected to Gene Death and Positive Selection

dc.contributor.author	Fouchécourt, Sophie
dc.contributor.author	Goudet, Ghylène
dc.contributor.author	Monget, Philippe
dc.contributor.author	Moros Nicolás, Carla
dc.contributor.department	Biología Celular e Histología
dc.date.accessioned	2024-01-23T17:33:44Z
dc.date.available	2024-01-23T17:33:44Z
dc.date.issued	2018
dc.description	©2018. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Accepted version of a Published Work that appeared in final form in ournal of Molecular Evolution. To access the final edited and published work see https://doi.org/10.1007/s00239-018-9878-0	es
dc.description.abstract	Oviductal proteins play an important role in mammalian fertilization, as proteins from seminal fluid. However, in contrast with the latter, their phylogenetic evolution has been poorly studied. Our objective was to study in 16 mammals the evolution of 16 genes that encode oviductal proteins involved in at least one of the following steps: (1) sperm–oviduct interaction, (2) acrosome reaction, and/or (3) sperm–zona pellucida interaction. Most genes were present in all studied mammals. However, some genes were lost along the evolution of mammals and found as pseudogenes: annexin A5 (ANXA5) and deleted in malignant brain tumor 1 (DMBT1) in tarsier; oviductin (OVGP1) in megabat; and probably progestagen-associated endometrial protein (PAEP) in tarsier, mouse, rat, rabbit, dolphin, and megabat; prostaglandin D2 synthase (PTGDS) in microbat; and plasminogen (PLG) in megabat. Four genes [ANXA1, ANXA4, ANXA5, and heat shock 70 kDa protein 5 (HSPA5)] showed branch-site positive selection, whereas for seven genes [ANXA2, lactotransferrin (LTF), OVGP1, PLG, S100 calcium-binding protein A11 (S100A11), Sperm adhesion molecule 1 (SPAM1), and osteopontin (SPP1)] branch-site model and model-site positive selection were observed. These results strongly suggest that genes encoding oviductal proteins that are known to be important for gamete fertilization are subjected to positive selection during evolution, as numerous genes encoding proteins from mammalian seminal fluid. This suggests that such a rapid evolution may have as a consequence that two isolated populations become separate species more rapidly	es
dc.format	application/pdf	es
dc.format.extent	13	es
dc.identifier.citation	Journal of Molecular Evolution
dc.identifier.doi	10.1007/s00239-018-9878-0
dc.identifier.issn	1432-1432
dc.identifier.issn	0022-2844
dc.identifier.uri	http://hdl.handle.net/10201/137613
dc.language	eng	es
dc.relation	This work was supported by INRA and grant from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No. 677353.	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Protein evolution	es
dc.subject	Oviduct	es
dc.subject	Fertilization	es
dc.subject	Pseudogene	es
dc.subject	Positive selection	es
dc.title	Genes Encoding Mammalian Oviductal Proteins Involved in Fertilization are Subjected to Gene Death and Positive Selection	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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