Publication: Genes Encoding Mammalian Oviductal Proteins Involved in Fertilization are Subjected to Gene Death and Positive Selection
Authors
Fouchécourt, Sophie ; Goudet, Ghylène ; Monget, Philippe ; Moros Nicolás, Carla
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Publisher
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DOI
10.1007/s00239-018-9878-0
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info:eu-repo/semantics/article
Description
©2018. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/
This document is the Accepted version of a Published Work that appeared in final form in ournal of Molecular Evolution. To access the final edited and published work see https://doi.org/10.1007/s00239-018-9878-0
Abstract
Oviductal proteins play an important role in mammalian fertilization, as proteins from seminal fluid. However, in contrast
with the latter, their phylogenetic evolution has been poorly studied. Our objective was to study in 16 mammals the evolution
of 16 genes that encode oviductal proteins involved in at least one of the following steps: (1) sperm–oviduct interaction, (2)
acrosome reaction, and/or (3) sperm–zona pellucida interaction. Most genes were present in all studied mammals. However,
some genes were lost along the evolution of mammals and found as pseudogenes: annexin A5 (ANXA5) and deleted in malignant brain tumor 1 (DMBT1) in tarsier; oviductin (OVGP1) in megabat; and probably progestagen-associated endometrial
protein (PAEP) in tarsier, mouse, rat, rabbit, dolphin, and megabat; prostaglandin D2 synthase (PTGDS) in microbat; and
plasminogen (PLG) in megabat. Four genes [ANXA1, ANXA4, ANXA5, and heat shock 70 kDa protein 5 (HSPA5)] showed
branch-site positive selection, whereas for seven genes [ANXA2, lactotransferrin (LTF), OVGP1, PLG, S100 calcium-binding
protein A11 (S100A11), Sperm adhesion molecule 1 (SPAM1), and osteopontin (SPP1)] branch-site model and model-site
positive selection were observed. These results strongly suggest that genes encoding oviductal proteins that are known to
be important for gamete fertilization are subjected to positive selection during evolution, as numerous genes encoding proteins from mammalian seminal fluid. This suggests that such a rapid evolution may have as a consequence that two isolated
populations become separate species more rapidly
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Citation
Journal of Molecular Evolution
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