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The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease

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dc.contributor.authorJanknecht, R.es
dc.date.accessioned2011-05-11T10:58:12Z
dc.date.available2011-05-11T10:58:12Z
dc.date.issued2002
dc.description.abstractp300 and CBP are highly homologous c o a c t ivators which promote gene transcription by bridging between DNA-binding transcription factors and the basal transcription machinery, by providing a s c a ffold for integrating transcription factors, and by modifying transcription factors and chromatin through acetylation. The p300/CBP cofactors are invo l ved in a plethora of physiological processes, and their activity is essential for embryogenesis. Chromosomal translocations affecting the p300 and Cbp genes are the cause of hematological malignancies, and C b p haploinsufficiency is a hallmark of the Rubinstein-Taybi syndrome. In addition, mutations in the C b p or p 3 0 0 gene, accompanied by loss of the other allele, have been found in various kinds of tumors. Furthermore, inhibition of CBP and p300 function in n e u r o d eg e n e r a t ive diseases caused by polyglutamine expansion may be an underlying cause for cytotoxicity. Approaches to modulate p300/CBP function may be instrumental in the development of novel therapies directed against viral infections, cancer and neurodegenerative diseases.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/20790
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCoactivatores
dc.subjectTumor suppressores
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísicaes
dc.titleThe versatile functions of the transcriptional coactivators p300 and CBP and their roles in diseasees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.17, nº 2 (2002)