Publication: The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease
Authors
Janknecht, R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
p300 and CBP are highly homologous
c o a c t ivators which promote gene transcription by
bridging between DNA-binding transcription factors and
the basal transcription machinery, by providing a
s c a ffold for integrating transcription factors, and by
modifying transcription factors and chromatin through
acetylation. The p300/CBP cofactors are invo l ved in a
plethora of physiological processes, and their activity is
essential for embryogenesis. Chromosomal
translocations affecting the p300 and Cbp genes are the
cause of hematological malignancies, and C b p
haploinsufficiency is a hallmark of the Rubinstein-Taybi
syndrome. In addition, mutations in the C b p or p 3 0 0
gene, accompanied by loss of the other allele, have been
found in various kinds of tumors. Furthermore,
inhibition of CBP and p300 function in
n e u r o d eg e n e r a t ive diseases caused by polyglutamine
expansion may be an underlying cause for cytotoxicity.
Approaches to modulate p300/CBP function may be
instrumental in the development of novel therapies
directed against viral infections, cancer and
neurodegenerative diseases.
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