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Ultrastructural pathology of the bone marrow in pigs inoculated with a moderately virulent strain (DR'78) of African swine fever virus

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dc.contributor.authorBautista, María Josées
dc.contributor.authorGómez-Villamandos, J. C.es
dc.contributor.authorCarrasco, L.
dc.contributor.authorRuíz-Villamor, E.
dc.contributor.authorSalguero, F.J.
dc.contributor.authorSierra, M. A.
dc.date.accessioned2011-02-22T10:59:10Z
dc.date.available2011-02-22T10:59:10Z
dc.date.issued1998
dc.description.abstractInterpretation of changes in bone marrow during infectious processes is quite complex. This paper reports bone marrow lesions observed in pigs inoculated with a moderately virulent ASF virus strain and studies their relationship to the pathogenesis of the disease. In this work, we have carried out the structural and ultrastructural study of the bone marrow of 14 Large White X Landrace pigs that were inoculatd by the intramuscular route with 105 50% hemodsorbing doses (HADSO) of the Dominican Republic178 ASF virus strain. The inoculated pigs were killed at 3, 5, 7, 9, 11, 13, 15 and 17 days postinjection. Analysis of cells and structures belonging to the two main bone-marrow compartments, the hematopoietic cells and the hematopoietic microenvironment, showed that after inoculation with a moderately virulent strain, the most significant changes occurred in macrophages and megakaryocytes, consisting in virus replication in these cell populations and apoptosis of megakaryocytes, related with the sudden and transitory thrombocytopenia detected in the subacute ASF.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19088
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectViruses
dc.subjectPathologyes
dc.subject.otherCDU::6 - Ciencias aplicadas::63 - Agricultura. Silvicultura. Zootecnia. Caza. Pesca::636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticoses
dc.titleUltrastructural pathology of the bone marrow in pigs inoculated with a moderately virulent strain (DR'78) of African swine fever viruses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.13, nº 3 (1998)