Publication: Ultrastructural pathology of the bone marrow in pigs inoculated with a moderately virulent strain (DR'78) of African swine fever virus
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Date
1998
Authors
Bautista, María José ; Gómez-Villamandos, J. C. ; Carrasco, L. ; Ruíz-Villamor, E. ; Salguero, F.J. ; Sierra, M. A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Interpretation of changes in bone marrow
during infectious processes is quite complex. This paper
reports bone marrow lesions observed in pigs inoculated
with a moderately virulent ASF virus strain and studies
their relationship to the pathogenesis of the disease. In
this work, we have carried out the structural and ultrastructural
study of the bone marrow of 14 Large White X
Landrace pigs that were inoculatd by the intramuscular
route with 105 50% hemodsorbing doses (HADSO) of the
Dominican Republic178 ASF virus strain. The inoculated
pigs were killed at 3, 5, 7, 9, 11, 13, 15 and 17 days
postinjection. Analysis of cells and structures belonging
to the two main bone-marrow compartments, the
hematopoietic cells and the hematopoietic microenvironment,
showed that after inoculation with a
moderately virulent strain, the most significant changes
occurred in macrophages and megakaryocytes,
consisting in virus replication in these cell populations
and apoptosis of megakaryocytes, related with the
sudden and transitory thrombocytopenia detected in the
subacute ASF.
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