Publication: Structure and molecular organization of dendritic spines
Authors
Tashiro, A. ; Yuste, R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Dendritic spines mediate most excitatory
synapses in the CNS and are therefore likely to be of
major importance for neural processing. We review the
structural aspects of dendritic spines, with particular
emphasis on recent advances in the characterization of
their molecular components. Spine morphology is very
diverse and spine size is correlated with the strength of
the synaptic transmission. In addition, the spine neck
biochemically isolates individual synapses. Therefore,
spine morphology directly reflects its function. A large
number of molecules have been described in spines,
involving several biochemical families. Considering the
small size of a spine, the variety of molecules found is
astounding, suggesting that spines are paramount
examples of biological nanotechnology. Singlemolecular
studies appear necessary for future progress.
The purpose of this rich molecular diversity is still
mysterious but endows synapses with a diverse and
flexible biochemical machinery.
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