Browsing by Subject "Computation"

Now showing 1 - 4 of 4
  • Thumbnail Image
    Publication
    Open Access
    Aritmética obligatoria : reflexiones de la historia al aula
    (Universidad de Zaragoza, Asociación Universitaria de Formación del Profesorado (AUFOP), 1994) Giménez, Joaquín
    En este artículo se justifican algunas reflexiones sobre el papel de la aritmética en la escuela obligatoria, desde un análisis que recorre la historia en tres períodos. Las aportaciones didácticas (desde una perspectiva básicamente intercultural). Tienen como objetivo el tratarniento de situaciones de aprendizaje que se relacionan con la propia historia de la Aritmética.
  • Thumbnail Image
    Publication
    Open Access
    Fijación de doctrina por el Tribunal Supremo sobre el día inicial para el cómputo del plazo en la reclamación de daños por una asistencia médica deficiente.
    (Universidad de Murcia, Servicio de Publicaciones, 2020) Latorre Luna, Leticia
    La importancia jurídica de la presente sentencia radica sustancialmente en que a través de la misma el Tribunal Supremo asienta una base doctrinal en relación a la fecha de inicio del cómputo del plazo para reclamar daños a causa de una asistencia médica defectuosa. En suma, como se podrá apreciar en el presente comentario, el Alto Tribunal establece que el “dies a quo” es el de la curación o estabilización del enfermo.
  • Thumbnail Image
    Publication
    Open Access
    Size-exclusion chromatography of macromolecules: a brief tutorial overview on fundamentals with computational tools for data analysis and determination of structural information
    (MDPI, 2025-02-22) Henández-Cifre, José Ginés; Collado-González, Mar; Díaz Baños, F. Guillermo; García de la Torre, José; Química Física; Ingeniería Química; Biología Celular e Histología
    Size-exclusion chromatography (SEC) is presently a widely used and very informative technique for the characterization of macromolecules in solution. Beyond the first implementations of SEC—which required cumbersome column calibrations and were mainly intended for the determination of molecular weights—the modern SEC approach involving multiple detectors (md-SEC) is based on solution properties such as intrinsic viscosity and light scattering. Thus, md-SEC enables the direct and more efficient determination of molecular weights, as well as the determination of relationships between property and molecular weight, which can be quite useful in structural studies. Here, we first present a review of the fundamental aspects of the dilute-solution properties of macromolecules—particularly the differential refractive index, intrinsic viscosity, and scattering-related properties—on which the various detectors involved in md-SEC are based. Then, we developed SECtools, a suite of public-domain, open-source computer programs, which allow for the full analysis of md-SEC chromatograms. These analyses range from just the recorded raw signals (mV) of the detectors to a full determination of molecular weight averages and distributions. The use of these programs is illustrated through experimental studies using various samples.
  • Thumbnail Image
    Publication
    Open Access
    Structure and molecular organization of dendritic spines
    (Murcia : F. Hernández, 2003) Tashiro, A.; Yuste, R.
    Dendritic spines mediate most excitatory synapses in the CNS and are therefore likely to be of major importance for neural processing. We review the structural aspects of dendritic spines, with particular emphasis on recent advances in the characterization of their molecular components. Spine morphology is very diverse and spine size is correlated with the strength of the synaptic transmission. In addition, the spine neck biochemically isolates individual synapses. Therefore, spine morphology directly reflects its function. A large number of molecules have been described in spines, involving several biochemical families. Considering the small size of a spine, the variety of molecules found is astounding, suggesting that spines are paramount examples of biological nanotechnology. Singlemolecular studies appear necessary for future progress. The purpose of this rich molecular diversity is still mysterious but endows synapses with a diverse and flexible biochemical machinery.