Publication: Localization of serotonin, cholecystokinin and somatostatin immunoreactivity in the lower respiratory tract of embryonic, foetal and postnatal sheep
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Date
1992
Authors
Balaguer, L. ; Romano, J. ; Ruíz-Pesini, P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The lower respiratory tract of the sheep was
studied by light-microscopical immunocytochemistry for
serotonin, cholecystokinin, somatostatin, bombesin and
calcitonin during different periods of lung development;
embryonic, foetal and postnatal. At embryonic period
only intraepithelial serotonin-containing cells as solitary
neuroendocrine cells (NEC) and neuroepithelial bodies
(NEB) were found. At foetal stages, immunoreactive
cells to serotonin, cholecystokinin and somatostatin were
observed in airway epithelium, as solitary NEC and
NEBs, and in autonomic intrapulmonary ganglia as
single or clusters of small intensely-fluorescent (SIF)
cells. In postnatal sheep, serotonin- and cholecystokinincontaining
cells were found within airway mucosa as
solitary NECs and NEBs. No immunoreactive cells were
observed with antiserum to bombesin and calcitonin.
Quantitative studies showed that serotonin was the
predominant substance, and that solitary neuroendocrine
cells were more numerous in dista1 conducting airways
and at foetal stages
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