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Astrocyte phenotypes: Emphasis on potential markers in neuroinflammation

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dc.contributor.authorBozic, Iva
dc.contributor.authorSavic, Danijela
dc.contributor.authorLavrnja, Irena
dc.date.accessioned2023-01-10T09:35:42Z
dc.date.available2023-01-10T09:35:42Z
dc.date.issued2021
dc.description.abstractAstrocytes, the most abundant glial cells in the central nervous system (CNS), have numerous integral roles in all CNS functions. They are essential for synaptic transmission and support neurons by providing metabolic substrates, secreting growth factors and regulating extracellular concentrations of ions and neurotransmitters. Astrocytes respond to CNS insults through reactive astrogliosis, in which they go through many functional and molecular changes. In neuroinflammatory conditions reactive astrocytes exert both beneficial and detrimental functions, depending on the context and heterogeneity of astrocytic populations. In this review we profile astrocytic diversity in the context of neuroinflammation; with a specific focus on multiple sclerosis (MS) and its best-described animal model experimental autoimmune encephalomyelitis (EAE). We characterize two main subtypes, protoplasmic and fibrous astrocytes and describe the role of intermediate filaments in the physiology and pathology of these cells. Additionally, we outline a variety of markers that are emerging as important in investigating astrocytic biology in both physiological conditions and neuroinflammation.es
dc.formatapplication/pdfes
dc.format.extent24es
dc.identifier.citationHistology and Histopathology Vol. 36, nº3 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-284
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/126990
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAstrocyteses
dc.subjectIntermediate filamentses
dc.subjectExperimental autoimmune encephalomyelitises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleAstrocyte phenotypes: Emphasis on potential markers in neuroinflammation
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36, nº3 (2021)