Publication: Identification of differentially expressed genes in fetal rat forebrain exposed to a teratogen by cDNA microarray analysis
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Date
2007
Authors
Dheen, S.T. ; Hao, A.J. ; Fu, J. ; Gopalakrishnakone, P. ; Ling, E. A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In an attempt to understand the molecular
basis underlying the neural tube defects induced by the
teratogen, cyclophosphamide (CP), cDNA microarray
analysis was carried out in neural tubes of embryos
derived from normal and CP-treated rats. Genes found to
have altered expression levels in CP-treated group were
clustered into groups on the basis of their biological
functions. The expression profile of different genes
involved in transcription of molecules related to cell
adhesion, inflammation, metabolism and neurotrophic
factors pathways as well as in still undefined processes
was differentially affected by the teratogen treatment.
The most remarkable change was the up-regulation of
genes related to an inflammatory process dominated by
the fetal brain macrophages viz. amoeboid microglia.
Amoeboid microglia/brain macrophage expansion, based
on gene expression and histological analysis, was found
to be vigorous at the subventricular region. The present
results suggest that a vigorous inflammatory response
involving amoeboid microglia/brain macrophages
primarily is an important component in CP-induced
prenatal development disorder.
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