Publication: Possible role of brown adipose tissue as a mediator during cyclosporine-A treatment
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Date
1994
Authors
Buján, J. ; Jurado, F. ; Gianonatti, M.C. ; Contreras, L.A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cyclosporine-A (CsA) is a potent immunosuppressor
used successfully to control rejection in organ
transplantation. According to the most recent evidence,
this drug modifies the lipid metabolism of the patient,
provoking a rise in the blood lipids, constituting an
important risk factor for acceleration of the atherogenic
process. Taking into account that brown adipose tissue
(BAT) constitutes the major storage site for cholesterol
and triglycerides in the rat, and given the apparent lack
of references about the implications of CsA on this
tissue in the literature, we proposed to study the possible
morphological changes occurring in BAT following the
administration of this drug.
Two groups of female Sprague-Dawley rats were set
up, the control group and a treated group in which each
animal received subcutaneous injection of 5 mglkg body
weightlday of CsA. After 4, l l , 25 and 34 days of
treatment, subgroups of animals were sacrificed and the
brown adipose tissue removed was apportioned for
subsequent microscopic assessment.
The greatest degree of atypia and activity in the BAT
was observed after administration of 11 doses of the
drug, at which point there was a marked reduction in the
cell size with loss of lipidic coalescence. With
subsequent doses, the tissue slowly initiated a process of
recovery.
CsA also induced morphological changes in the BAT
that. in the early stages of the study, appeared to be
correlated with a lipolytic response of the tissue to the
drug; thus, the BAT may be acting as a system to
eliminate the excess of lipids in the blood provoked by
CsA administration, while toward the end of treatment,
there was a certain stability between the drug and the
activity of the brown adipose tissue, and a tendency to
reach a balance between lipolysis and lipogenesis.
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