Publication:
Adenosine deaminase, not immune to a mechanistic rethink in central nervous system disorders?

Simple item page
dc.contributor.authorHall, Benjamin
dc.contributor.authorGeorge, Jonathan G.
dc.contributor.authorAllen, Scott P.
dc.date.accessioned2023-02-10T09:02:53Z
dc.date.available2023-02-10T09:02:53Z
dc.date.issued2022
dc.description.abstractAdenosine deaminase (ADA) is a purine metabolism enzyme that catalyses the breakdown of adenosine and deoxyadenosine. The enzyme is important in several cellular processes, including the innate immune response and cellular differentiation, and it is also an important enzyme for the maintenance of brain homeostasis, in part due to its regulation of adenosine. Aberrant regulation of ADA enzyme activity has been linked to several neurodegenerative diseases and diseases that can result in neurological impairment. However, the mechanisms behind altered ADA regulation and how this leads to the development of neurological dysfunction are poorly characterised. This review summarises the current research on ADA and its role and regulation in disease pathology, with a focus on the central nervous system (CNS) and the neurodegenerative disease, amyotrophic lateral sclerosis (ALS)es
dc.formatapplication/pdfes
dc.format.extent24es
dc.identifier.citationHistology and Histopathology Vol. 37, nº3 (2022)
dc.identifier.doihttps://doi.org/ 10.14670/HH-18-404
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/128325
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAdenosine deaminasees
dc.subjectCentral nervous systemes
dc.subjectPathologyes
dc.subjectSevere combined immunodeficiencyes
dc.subjectAmyotrophic lateral sclerosises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleAdenosine deaminase, not immune to a mechanistic rethink in central nervous system disorders?es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Hall-37-189-212-2022.pdf
Size:
4.37 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.37, nº3 (2022)