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Down regulation of gastric and intestinal phenotypic expression in Epstein-Barr virus-associated stomach cancers

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dc.contributor.authorHirano, N.es
dc.contributor.authorTsukamoto, T.es
dc.contributor.authorMizoshita, T.
dc.contributor.authorKoriyama, C.
dc.contributor.authorAkiba, S.
dc.contributor.authorCampos, F.
dc.contributor.authorCarrasquilla, G.
dc.contributor.authorCarrascal Marino, E.
dc.contributor.authorCao, X.
dc.contributor.authorToyoda, T.
dc.contributor.authorBan, H.
dc.contributor.authorMiki, K.
dc.contributor.authorTatematsu, M.
dc.date.accessioned2012-05-21T12:09:53Z
dc.date.available2012-05-21T12:09:53Z
dc.date.issued2007
dc.description.abstractimportance of gastric and intestinal phenotypic expression for stomach carcinogenesis. In this study, we focused on Epstein-Barr virus (EBV)-associated stomach cancers, with special attention to Cdx2. Methods and Results: We evaluated the expression of gastric and intestinal phenotypic markers by immunohistochemistry in 35 EBV-positive [EBV (+)] and 75 EBV-negative [EBV (-)] stomach cancers in Colombia. The lesions were divided phenotypically into gastric (G), gastric-and-intestinal mixed (GI), intestinal (I), and null (N) phenotypes. In the EBV (+) cases, the lesions were divided phenotypically into 9 G (25.7%), 1 GI (2.9%), 3 I (8.6%), and 22 N (62.9%) types. Similarly, the EBV (-) lesions were also classified phenotypically as 15 G (20.0%), 19 GI (25.3%), 24 I (32.0%), and 17 N (22.7%) types. The proportion of N type EBV (+) lesions was higher than for their EBV (-) counterparts (P<0.0001). The expression of Cdx2 and MUC2 was also found to be significantly lower in EBV (+) than in EBV (-) stomach cancers (P=0.0001; P<0.0001). Cdx2 expression in the intestinal metaplastic glands present in non-neoplastic mucosa surrounding EBV (+) lesions was also significantly lower than in EBV (-) tumors (P=0.016) despite no evidence of EBV infection by low expression of intestinal phenotype markers, including Cdx2, and only occasional gastric phenotypic expression.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/27597
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectStomach cancerses
dc.subjectEpstein-Barr viruses
dc.subject.other616.3 - Patología del aparato digestivo. Odontologíaes
dc.titleDown regulation of gastric and intestinal phenotypic expression in Epstein-Barr virus-associated stomach cancerses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.22, nº 6 (2007)