Publication: Down regulation of gastric and intestinal phenotypic expression in Epstein-Barr virus-associated stomach cancers
Loading...
Date
2007
Authors
Hirano, N. ; Tsukamoto, T. ; Mizoshita, T. ; Koriyama, C. ; Akiba, S. ; Campos, F. ; Carrasquilla, G. ; Carrascal Marino, E. ; Cao, X. ; Toyoda, T. ; Ban, H. ; Miki, K. ; Tatematsu, M.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
importance of gastric and intestinal phenotypic
expression for stomach carcinogenesis. In this study, we
focused on Epstein-Barr virus (EBV)-associated
stomach cancers, with special attention to Cdx2.
Methods and Results: We evaluated the expression of
gastric and intestinal phenotypic markers by
immunohistochemistry in 35 EBV-positive [EBV (+)]
and 75 EBV-negative [EBV (-)] stomach cancers in
Colombia. The lesions were divided phenotypically into
gastric (G), gastric-and-intestinal mixed (GI), intestinal
(I), and null (N) phenotypes. In the EBV (+) cases, the
lesions were divided phenotypically into 9 G (25.7%), 1
GI (2.9%), 3 I (8.6%), and 22 N (62.9%) types.
Similarly, the EBV (-) lesions were also classified
phenotypically as 15 G (20.0%), 19 GI (25.3%), 24 I
(32.0%), and 17 N (22.7%) types. The proportion of N
type EBV (+) lesions was higher than for their EBV (-)
counterparts (P<0.0001). The expression of Cdx2 and
MUC2 was also found to be significantly lower in EBV
(+) than in EBV (-) stomach cancers (P=0.0001;
P<0.0001). Cdx2 expression in the intestinal metaplastic
glands present in non-neoplastic mucosa surrounding
EBV (+) lesions was also significantly lower than in
EBV (-) tumors (P=0.016) despite no evidence of EBV
infection by low expression of intestinal phenotype markers,
including Cdx2, and only occasional gastric phenotypic
expression.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.