Publication:
Low expression of Progesterone Receptor A in intermediate trophoblast of miscarriages

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dc.contributor.authorPapamitsou, Theodora
dc.contributor.authorChatzistamatiou, Maria
dc.contributor.authorGrammatikopoulou, Danai
dc.contributor.authorPapadopoulou, Kyriaki
dc.contributor.authorLakis, Sotirios
dc.contributor.authorEconomou, Zinon
dc.contributor.authorPapadopoulou, Chrisi
dc.contributor.authorSioga, Antonia
dc.date.accessioned2016-04-18T10:49:55Z
dc.date.available2016-04-18T10:49:55Z
dc.date.issued2011
dc.description.abstractSummary. Objective: To examine the potential differences in the expression of Progesterone Receptor A and Estrogen Receptor A in intermediate trophoblastic cells at the implantation site in elective abortions and miscarriages by immunohistochemistry. Study Design: Twenty two (22) samples of miscarriages and eighteen (18) samples of elective abortions were obtained during gestational weeks 6 to 12. Monoclonal antibodies against Cytokeratin 7 and prolactin were used to help discriminate between trophoblastic and decidual cells at the feto-maternal interface on formalin-fixed paraffin-embedded sections. Samples were then stained with ERA and PRA antibodies. Nuclear expression was considered positive. Staining intensity was measured according to a 4 grade scale. Statistical analysis of the results was performed using the Mann-Whitney test and the Wilcoxon signed rank test. Results: PRA expression in intermediate trophoblastic cells was significantly higher in elective abortions (control group) compared to miscarriages. ERA expression was uniformly negative in both groups. Conclusion: PRA expression is significantly lower in intermediate trophoblastic cells of miscarriages compared to elective abortion pregnancies. Although this could be solely a result of a secondary event, it is still an important finding in the effort to unravel the complex molecular pathobiology of spontaneous abortions.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/48633
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and Histopathology,vol25, nº5, 2011es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectProgesterone receptor Aes
dc.subjectEstrogen receptor Aes
dc.subjectIntermediate trophoblastes
dc.subject.other61 - Medicinaes
dc.titleLow expression of Progesterone Receptor A in intermediate trophoblast of miscarriageses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº5 (2011)