Publication: Low expression of Progesterone Receptor A
in intermediate trophoblast of miscarriages
Authors
Papamitsou, Theodora ; Chatzistamatiou, Maria ; Grammatikopoulou, Danai ; Papadopoulou, Kyriaki ; Lakis, Sotirios ; Economou, Zinon ; Papadopoulou, Chrisi ; Sioga, Antonia
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Summary. Objective: To examine the potential
differences in the expression of Progesterone Receptor A
and Estrogen Receptor A in intermediate trophoblastic
cells at the implantation site in elective abortions and
miscarriages by immunohistochemistry.
Study Design: Twenty two (22) samples of
miscarriages and eighteen (18) samples of elective
abortions were obtained during gestational weeks 6 to
12. Monoclonal antibodies against Cytokeratin 7 and
prolactin were used to help discriminate between
trophoblastic and decidual cells at the feto-maternal
interface on formalin-fixed paraffin-embedded sections.
Samples were then stained with ERA and PRA
antibodies. Nuclear expression was considered positive.
Staining intensity was measured according to a 4 grade
scale. Statistical analysis of the results was performed
using the Mann-Whitney test and the Wilcoxon signed
rank test.
Results: PRA expression in intermediate
trophoblastic cells was significantly higher in elective
abortions (control group) compared to miscarriages.
ERA expression was uniformly negative in both groups.
Conclusion: PRA expression is significantly lower
in intermediate trophoblastic cells of miscarriages
compared to elective abortion pregnancies. Although
this could be solely a result of a secondary event, it is
still an important finding in the effort to unravel the
complex molecular pathobiology of spontaneous
abortions.
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