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Decreased long-term severe acute respiratory syndrome coronavirus 2–specific humoral immunity in liver transplantation recipients 12 months after coronavirus disease 2019

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dc.contributor.authorCaballero-Marcos, Aránzazu
dc.contributor.authorCitores, María Jesús
dc.contributor.authorAlonso-Fernández, Roberto
dc.contributor.authorRodriguez-Perálvarez, Manuel
dc.contributor.authorValerio, Maricela
dc.contributor.authorGraus Morales, Javier
dc.contributor.authorCuervas-Mons, Valentín
dc.contributor.authorCachero, Alba
dc.contributor.authorLoinaz-Segurola, Carmelo
dc.contributor.authorIñarrairaegui, Mercedes
dc.contributor.authorCastells, Lluís
dc.contributor.authorPascual, Sonia
dc.contributor.authorVinaixa-Aunés, Carmen
dc.contributor.authorGonzález-Grande, Rocío
dc.contributor.authorOtero, Alejandra
dc.contributor.authorTomé, Santiago
dc.contributor.authorTejedor-Tejada, Javier
dc.contributor.authorFernández-Yunquera, Ainhoa
dc.contributor.authorGonzález-Diéguez, Luisa
dc.contributor.authorNogueras-López, Flor
dc.contributor.authorBlanco-Fernández, Gerardo
dc.contributor.authorDíaz-Fontenla, Fernando
dc.contributor.authorBustamante, Francisco Javier
dc.contributor.authorRomero-Cristóbal, Mario
dc.contributor.authorMartin-Mateos, Rosa
dc.contributor.authorArias-Millas, Ana
dc.contributor.authorCalatayud, Laura
dc.contributor.authorMarcacuzco-Quinto, Alberto A.
dc.contributor.authorFernández-Alonso, Victor
dc.contributor.authorGómez-Gavara, Concepción
dc.contributor.authorMuñoz, Patricia
dc.contributor.authorBañares, Rafael
dc.contributor.authorPons Miñano, José Antonio
dc.contributor.authorSalcedo, Magdalena
dc.contributor.departmentMedicina
dc.date.accessioned2025-01-26T11:14:15Z
dc.date.available2025-01-26T11:14:15Z
dc.date.issued2022-01-17
dc.description© 2021 by the American Association for the Study of Liver Disease. This document is the Published version of a Published Work that appeared in final form in Liver Transplantation. To access the final edited and published work see https://doi.org/10.1002/lt.26389
dc.description.abstractLong-term humoral immunity and its protective role in liver transplantation (LT) patients have not been elucidated. We performed a prospective multicenter study to assess the persistence of immunoglobulin G (IgG) antibodies in LT recipients 12 months after coronavirus disease 2019 (COVID-19). A total of 65 LT recipients were matched with 65 nontransplanted patients by a propensity score including variables with recognized impact on COVID-19. LT recipients showed a lower prevalence of anti-nucleocapsid (27.7% versus 49.2%; P = 0.02) and anti-spike IgG antibodies (88.2% versus 100.0%; P = 0.02) at 12 months. Lower index values of anti-nucleocapsid IgG antibodies were also observed in transplantation patients 1 year after COVID-19(median, 0.49 [interquartile range, 0.15-1.40] versus 1.36 [interquartile range, 0.53-2.91]; P < 0.001). Vaccinated LT recipients showed higher antibody levels compared with unvaccinated patients (P < 0.001); antibody levels reached after vaccination were comparable to those observed in nontransplanted individuals (P = 0.70). In LT patients, a longer interval since transplantation (odds ratio, 1.10; 95% confidence interval, 1.01-1.20) was independently associated with persistence of anti-nucleocapsid IgG antibodies 1 year after infection. In conclusion, compared with nontransplanted patients, LT recipients show a lower long-term persistence of anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. However, SARS-CoV-2 vaccination after COVID-19 in LT patients achieves a significant increase in antibody levels, comparable to that of nontransplanted patients.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationLiver Transplantation 28 1040‒1050 2022
dc.identifier.doihttps://doi.org/10.1002/lt.26389
dc.identifier.urihttp://hdl.handle.net/10201/149316
dc.languageenges
dc.publisherWileyes
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://journals.lww.com/lt/abstract/2022/06000/decreased_long_term_severe_acute_respiratory.20.aspx
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSARS-2es
dc.subjectCOVID
dc.subjectHumoral Immunity
dc.subjectLiver transplantation
dc.titleDecreased long-term severe acute respiratory syndrome coronavirus 2–specific humoral immunity in liver transplantation recipients 12 months after coronavirus disease 2019es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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