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TGF-β links glycolysis and immunosuppression in glioblastoma

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dc.contributor.authorGong, Lingli
dc.contributor.authorJi, Li
dc.contributor.authorXu, Daxing
dc.contributor.authorWang, Jingjing
dc.contributor.authorZou, Jian
dc.date.accessioned2023-01-31T09:41:20Z
dc.date.available2023-01-31T09:41:20Z
dc.date.issued2021
dc.description.abstractGlioblastoma (GBM) is the most common and aggressive brain tumor in adults, characterized by diffuse infiltration, dysplasia, and resistance to therapy. Metabolic remodeling and immunosuppression are typical events which contribute to GBM progression, but the molecular link between these two events remains largely undetermined. Studies have shown that high levels of transforming growth factor-β (TGF-β) and its receptors are associated with glioma malignancy and a poor prognosis. TGF-β plays an important role in cell metabolism and immunity. During tumorigenesis, TGFβ induces a shift in cell metabolism from oxidative phosphorylation to aerobic glycolysis, providing a favorable environment for tumor growth. Locally, TGFβ creates an immunosuppressive microenvironment and promotes the malignant phenotype of GBM. In this review, we aim to link GBM aerobic glycolysis and immunosuppression through TGF-β to provide new ideas for the study of GBM.es
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dc.format.extent14es
dc.identifier.citationHistology and Histopathology Vol. 36, nº11 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-366
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/127983
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectTGF-βes
dc.subjectImmunosuppressiones
dc.subjectGBMes
dc.subjectGlycolysises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleTGF-β links glycolysis and immunosuppression in glioblastomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36,nº11 (2021)