Publication: TGF-β links glycolysis and immunosuppression in glioblastoma
Authors
Gong, Lingli ; Ji, Li ; Xu, Daxing ; Wang, Jingjing ; Zou, Jian
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-366
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info:eu-repo/semantics/article
Description
Abstract
Glioblastoma (GBM) is the most common
and aggressive brain tumor in adults, characterized by
diffuse infiltration, dysplasia, and resistance to therapy.
Metabolic remodeling and immunosuppression are
typical events which contribute to GBM progression, but
the molecular link between these two events remains
largely undetermined. Studies have shown that high
levels of transforming growth factor-β (TGF-β) and its
receptors are associated with glioma malignancy and a
poor prognosis. TGF-β plays an important role in cell
metabolism and immunity. During tumorigenesis, TGFβ induces a shift in cell metabolism from oxidative
phosphorylation to aerobic glycolysis, providing a
favorable environment for tumor growth. Locally, TGFβ creates an immunosuppressive microenvironment and
promotes the malignant phenotype of GBM. In this
review, we aim to link GBM aerobic glycolysis and
immunosuppression through TGF-β to provide new
ideas for the study of GBM.
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Citation
Histology and Histopathology Vol. 36, nº11 (2021)
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