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In vitro antigen-specific cytotoxic T cell response against esophageal carcinoma cells induced by HPV18E7-transfected dendritic cells

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dc.contributor.authorWu, Lines
dc.contributor.authorYang, Weies
dc.contributor.authorChen, Lin-Xin
dc.contributor.authorChen, Shen-Ren
dc.contributor.authorZhang, Jin-Kun
dc.date.accessioned2015-01-20T12:06:08Z
dc.date.available2015-01-20T12:06:08Z
dc.date.issued2010
dc.description.abstractHuman Papillomavirus (HPV)-associatedesophageal carcinoma (EC) is a high incidence tumorworldwide. Dendritic cell (DC)-based tumor vaccine isconsidered an alternative therapy to treat EC. Here wedeveloped a DC-based vaccine by transfecting cordblood CD34+stem cell-derived DC with HPV18E7gene, observed its biological characteristics and theantigen-specific T-cell cytotoxicity on EC cells inducedby HPV18E7-DC in vitro. Our results showed that 1)HPV18E7 gene transfer did not change the typicalmorphology of mature DC, 2) the representativephenotypes of mature DC (CD80, CD86, and CD83)were highly expressed in HPV18E7- DC (81.6%, 80.5%,and 86.6%, respectively), 3) the expression level of18E7 protein in HPV18E7-DC was 47.5%, and 4) thespecific cytotoxicity against EC cells was significantlyhigher than that in controls (p<0.01). This studyindicates the possibility of a DC-based immunotherapyin HPV-associated EC.en_EN
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/42580
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectDendritic celles
dc.subjectImmunotherapyes
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleIn vitro antigen-specific cytotoxic T cell response against esophageal carcinoma cells induced by HPV18E7-transfected dendritic cellses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25, nº2 (2010)